Association between sequence variations in genes encoding human zona pellucida glycoproteins and fertilization failure in IVF
نویسندگان
چکیده
منابع مشابه
1 Zona Pellucida Glycoproteins
Abbreviations: ZP, zona pellucida; ZPG, ZP glycoprotein; VE, vitelline envelope; VEG, VE glycoprotein; mZP, mouse ZP; hZP, human ZP; SS, signal sequence; CTP, C-terminal propeptide; CFCS, consensus furin cleavage-site; TMD, transmembrane domain; ZPD, ZP domain; NTS, N-terminal subdomain; CTS, C-terminal subdomain; EHP, external hydrophobic patch; IHP, internal hydrophobic patch; CP, charged pat...
متن کاملCharacterization of human zona pellucida glycoproteins.
The human egg may only be fertilized by one spermatozoon to prevent polyploidy. In most mammals, the primary block to polyspermy occurs at the zona pellucida (ZP). Little is known of the human ZP and the changes occurring following fertilization to prevent polyploidy. Using antibodies directed against synthetic peptides predicted from the human ZP2 and ZP3 cDNA, we identified ZP3 as a 53-60 kDa...
متن کاملCorrelation between morphological abnormalities in the human oocyte zona pellucida, fertilization failure and embryonic development
Objective: The general patient condition, oocyte and embryo condition and clinical outcomes were studied in patients with a morphologically abnormal zona pellucida (ZP). Methods: The general embryo condition was compared between patients with a morphologically abnormal ZP or a normal ZP. The general embryo conditions in the first and subsequent cycles were compared in patients with a morphologi...
متن کاملFour zona pellucida glycoproteins are expressed in the human.
BACKGROUND The zona pellucida (ZP) is an extracellular glycoprotein matrix which surrounds all mammalian oocytes. Recent data have shown the presence of four human zona genes (ZP1, ZP2, ZP3 and ZPB). The aim of the study was to determine if all four ZP proteins are expressed and present in the human. METHODS cDNA derived from human oocytes were used to amplify by PCR the four ZP genes. In add...
متن کاملNative human zona pellucida glycoproteins: purification and binding properties.
BACKGROUND Fertilization starts with the binding of the spermatozoa to the zona pellucida (ZP) of the oocyte. Such binding is a carbohydrate-mediated event and consists of a series of tightly regulated events. Molecular interactions between spermatozoon and ZP in human are not well characterized due to limited availability of oocytes for research. Our current technology cannot generate recombin...
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ژورنال
عنوان ژورنال: Human Reproduction
سال: 2005
ISSN: 1460-2350,0268-1161
DOI: 10.1093/humrep/deh837